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Signal
Transduction (Biol 7226)
Syllabus
| Week
1 |
Placement
Test and Introduction (VU) |
| Week
2 |
Intracellular
Receptors (VU) |
| Week
3 |
Quiz
Introduction to VU lectures |
| Week
4 |
Cell
Surface Receptors and G Protein Coupling Pathways (VU) |
| Week
5 |
cAMP
and cGMP Dependent Pathways (VU) |
| Week
6 |
Ca++
Dependent Pathways (VU) |
| Week
7 |
Midtern |
| Week
8 |
IP3
and DAG Dependent Pathways (VU) |
| Week
9 |
Phosphorylation
and Dephosphorylations (VU) |
| Week
10 |
The
Oncogenes (VU) |
| Week
11 |
Receptor
Tyrosine Kinase (VU) |
| Week
12 |
Interactions
between pathways (VU) |
| Week
13 |
Student
Presentations |
| Week
14 |
Proposals
due |
| Week
15 |
Final
Exam during the University Final Week |
Please
note the above information is subject to change.
Reading
materials:
Chapters 4, 15, 19 in Molecular Biology of The Cell (3rd edition;
Albert, B. et al; 1994).
Chapter 4 helps you to review some basic cell biol, biochem and
mol biol techniques which may be discussed in this class.
Chapter 15 provides a good summary of signal transduction studies.
Chapter 19 provides information concerning intercellular communication.
Other supplemental readings including review articles will be assigned
(1-3 research articles directly related to the lectures per week).
The journals include
Science, J of Biol. Chem., J of Neuroscience, Proceedings of
the National Academy of Sciences, Cell Signaling, Nature, Brain
Research, Molecular and Cellular Neuroscience, etc. All lecture
content and reading materials will be included on the exams.
Attendence
Students are expected to attend all lectures. If a lecture or test
is canceled due to inclement weather, that lecture material or test
will be given at the next scheduled lecture period.
Examinations and Grading
Exams:
1 placement test
1 quiz
1 midterm exam
1 final exam
Please note that all exams are cumulative. Make-up exams will only
be given if the student has a valid, serious excuse.
Students are required to prepare a research proposal on a selected
topic of signal transduction which cannot be your thesis project
or your project at work. In addition, each student will be required
to give a 10-15 minute presentation of this proposal, followed by
a 3-5 minute discussion.
Grades:
Final grades will be determined as follows:
| Placement
test |
0% |
| Quiz |
10% |
| Midterm
exam |
30% |
| Final
exam |
30% |
| Proposal
presentation, discussion |
30% |
Grading
scale:
| 90%
- 100 % |
A |
| 85%
- 89 % |
B+ |
| 80%
- 84 % |
B |
| 75%
- 79 % |
C+ |
| 70%
- 74 % |
C |
| Below
70 % |
F |
Your
grades may be obtained in my office.
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