Methods
in Neuroscience (Biol 6335)
Syllabus
This
course will consist of 5 parts:
PART
I:
14 weeks: lectures (150 minutes per week) as follow
| Module
1: |
Introduction
(IACUC and IBR, responsible conduct of research) |
| Module
2: |
Behavior
Testing* |
| Module
3: |
Neuropharmacology* |
| Module
4: |
Receptor
Binding Techniques: Auto radiography and Biochemistry* |
| Module
5: |
Stereotaxic
Surgery: Histological Techniques, Brain Dissection |
| Module
6: |
Track
Tracing (Neuronal Tracking) |
| Module
7: |
Immunohistochemistry:
Light Microscopy and Image Analysis* |
| Module
8: |
Electron
Microscopy |
| Module
9: |
Electro
physiology: Single Cell* |
| Module
10: |
Electro
physiology: Slices* |
| Module
11: |
Isolation
and characterization of Neurotransmitters |
| |
(HPLC,
NMR and Mass Spec) |
| Module
12: |
Confocal
Microscopy and Intracellular Calcium Measurements* |
| Module
13: |
Functional
MRI* |
| Module
14: |
Use
of modern molecular biology |
*Various
statistic analysis techniques will be utilized along with these
methods.
PART
II:
Four additional invited lectures will be presented in conjunction
with Neuroscience seminars.
PART
III:
1 week for two one hour mid-term exams.
PART
IV:
1 week for selected topic discussion and student presentations.
PART
V:
Final EXAM will be given in the University Finals Week.
Required Text:
Principles of Neural Science, 4th Ed., E.R. Kandel, J.H.
Schwartz, T.M. Jessell (Eds.),
McGraw Hill, 2000
Selected articles from scientific publications including:
Science, Nature, J of Neurosciences, Proceedings of the National
Academy of Sciences, Brain Research, Neuron, etc will be included
as reading assignment.
The materials on both text and assigned readings will be included
on the test.
Attendance:
Students are expected to attend all lectures. In addition, there
will be selected invited lectures that will be presented in conjunction
with the Neuroscience Seminars. The materials presented in these
lectures will also be included on the tests. If a lecture or test
is canceled due to inclement weather, that lecture material or test
will be given at the next scheduled lecture period.
Examination and Grading:
Exams:
2 one-hour exams
1 final exam
Please note that all exams are cumulative. Make-up exams will only
be given if the student has a valid, serious excuse. Students are
also required to prepare a research proposal on selected topics
of Neuroscience. In addition, each student will be required to give
a 10-15 minute presentation on this proposal, followed by a 3-5
minute discussion.
Grading
Policy:
Final grades will be determined as follows:
30% final (cumulative and comprehensive)
20% hour exam
20% hour exam
20% proposal
10% attendance and participation
The
student must attain:
90% or more to attain an A
85-89% for a B+
80-84% for a B
75-79% for a C+
70-74% for a C
A grade less than 70% will result in failing.
Grades
may be obtained in the instructor's office.
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