Typical questions from past Toxicology Exams

1. Why is the LD50 used to compare the affects of different toxicants?


2. Based on the log dose-probit plot, what dose might you use for a chronic study? Why?

3. Quinine is an antimalarial drug given when patients have reoccurring problems.

Studies have shown the following.

% absorbed            pKa = 8.4                                                pH4 =9         pH8 =54

Where would quinine be absorbed in the GI tract and why?

4. Using the graph in Fig. 1 showing log plasma concentration (mg/L) versus time after dose (h) determine:

A. the original plasma concentration.

B. The elimination rate

5. Draw a potential phase I metabolite for aniline. Where would it be eliminated?