TOXICOLOGY 7228NB  Fall, 2000


Dr. Carolyn Bentivegna

Telephone: 973-275-2113

McNulty Hall Room #208

OFFICE HOURS: MW, 10-12:00 A.M. or by appointment

LECTURES: R 7-9:30, rm 62 Corrigan Hall (CH)

TEXTBOOK: Toxicology: Principles and Applications (1st edition) Raymond J. M. Niesink, John de Vries, and Mannfred A. Hollinger, Eds., CRC Press Inc., New York, 1996.


9/7 fundamental principles/toxicity testing 
Chp. 1, 2, 7
9/14 biotransformation/computer lab (McNulty, rm. 206)
Chp. 3 
9/20 factors that modify toxicity/ADE
Chp. 4, 5
9/28 toxicokinetics/computer lab
Chp. 6
10/5 Exam I/ general mechanisms of toxicity
10/12 apoptosis/free radicals
Chp. 10, 16
10/19 lipid peroxidation/adduct formation 
Chp. 10 & HO
10/26 mutagenesis
*1st paper due, paper discussion
Chp. 11,
11/2 carcinogenesis/risk evaluation  (guest speaker)
Chp. 12, 13, 14
11/9 Exam II /dermatotoxicology
Chp. 17
inhalation toxicology/hepatic toxicology
Chp. 18, 22, 23
11/30 nephrotoxicology
*2nd paper due, paper discussion
Chp. 24
12/7 neurotoxicology 
Chp. 33, 34
12/14 reproductive toxicology 
*3rd paper due, paper discussion 
Chp. 31
12/21 Exam III


Assignment Points Final points Final percentage Grade
Exam I 100 400-360 100-90% A
Exam II 100 359-340 89-85% B+
Exam III 100 339-320 84-80% B
Paper 1-3 25 each 319-300 79-75% C+
Computer lab 1 10 299-280 74-70% C
Computer lab 2 15 <280 < 70 % F

Exams are not cumulative, and their dates are fixed.  Makeups are permissible but only for very good reasons, i.e. medical emergencies, and they will be given at my convenience.  Exams will be given at the beginning of the period and end at 8:15 P.M..  I will start them at 6:45 for those students that want extra time.  If you are caught cheating on an exam or plagiarizing, you will be given zero credit for that assignment.

There will be two computer labs.  The first one is on toxicity testing where LC50s will be generated and evaluated using computer software.  The second lab involves using a pharmacokinetic computer program to study toxicokinetics.  There will be a handout for both of these assignments which must be completed by the next class.

You will critique journal articles given to you in class.  The papers should include a section for the introduction, methods, results, and conclusions.  In your critique, consider the purpose for doing the experiment, what the hypotheses were, how suitable the approach and methods were to the objectives, and whether the data justify the authors conclusions.  Include positive and negative aspects as well as correlations with lecture material.  Be precise, each paper should not be more than three typed pages, double spaced, with a 12 point font.  Papers are due on or before the scheduled date.  A missed assignment will be worth zero credit.  One grade will be dropped for every day a paper is late.  See an example by following the link at the beginning of the syllabus.